Journal
TETRAHEDRON-ASYMMETRY
Volume 21, Issue 4, Pages 429-436Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.02.022
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Funding
- Nanyang Technological University [RG27/07]
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New highly constrained chiral C-1-1,1'-bisisoquinoline ligands have been synthesized. X-ray crystallographic analysis of these ligands showed peculiar structural differences between the parent 1',2',3',4'-tetrahydro-1,1'-bisisoquinoline and its alkyl, acyl and sulfonyl derivatives. The consequences of their geometrical conformations on enantioinduction were examined by employing the enantioselective addition of diethylzinc to aldehydes. Such conformations greatly affected the catalytic efficiency of these ligands. (C) 2010 Elsevier Ltd. All rights reserved.
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