4.0 Article

Axially chiral C2-symmetric N-heterocyclic carbene (NHC) palladium complex-catalyzed asymmetric α-hydroxylation of β-keto esters

Journal

TETRAHEDRON-ASYMMETRY
Volume 21, Issue 21-22, Pages 2675-2680

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.10.031

Keywords

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Funding

  1. Shanghai Municipal Committee of Science and Technology [08dj1400100-2]
  2. National Basic Research Program of China (973) [2010CB833302]
  3. National Natural Science Foundation of China [20902019, 20872162, 20672127, 20821002, 20732008, 20702059]

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Axially chiral C-2-symmetric N-heterocyclic carbene (NHC) palladium diaquo complexes 1a and 1b derived from (R)-BINAM are effective catalysts for the enantioselective alpha-hydroxylation of beta-keto esters using oxaziridine 2a as the oxidant to give the corresponding products in high yields along with moderate enantioselectivities (C) 2010 Elsevier Ltd All rights reserved

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