Journal
TETRAHEDRON-ASYMMETRY
Volume 20, Issue 1, Pages 65-67Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2009.01.011
Keywords
-
Funding
- Spanish Ministerio de Ciencia e Innovacion [2010/CSD2007-00006, CTQ2007-65218/BQU]
- University of Alicante (UA)
Ask authors/readers for more resources
The catalytic enantioselective addition of different organozinc reagents, such as diethylzinc, or in situ generated phenylzinc derivatives to simple aryl methyl ketones was accomplished using titanium tetra-isopropoxide and a polymeric ligand grafted with trans-1-phenylsulfonylamino-2-isoborneolsulfonylamidocyclohexane, to give the corresponding tertiary alcohols with enantioselectivities of up to >99% ee. Whereas the highest enantioselectivities were obtained in the ethylation process, the highest chemical yields were obtained in the phenylation process. The ligand could be re-used at least three times Without any significant loss of activity. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available