4.0 Article

DNA-based hydrolytic kinetic resolution of epoxides

Journal

TETRAHEDRON-ASYMMETRY
Volume 19, Issue 20, Pages 2374-2377

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.10.004

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Funding

  1. NWO-CW

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DNA-bound copper(H) complexes serve as catalysts for the hydrolytic kinetic resolution of 2-pyridyloxiranes in water. Selectivity factors of up to 2.7 were achieved, indicating a chirality transfer of DNA to epoxides via a coordinated metal ion. (C) 2008 Elsevier Ltd. All rights reserved.

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