Journal
TETRAHEDRON-ASYMMETRY
Volume 19, Issue 11, Pages 1376-1380Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.05.005
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The addition of dialkylzinc reagents to N-(diphenylphosphinoyl)imines in the presence of a catalytic amount of a beta-aminoalcohol with the prolinol framework under microwave irradiation gives the expected addition products in good yields and with an ee of up to 92%. The reaction times (2030 min) are much shorter than the ones observed in the same reactions performed at room temperature without microwave irradiation. In most cases, in the microwave-promoted reactions yields improve and enantiomeric excesses are very close to the ones achieved in the reactions stirred at room temperature. High enantioselectivities are obtained in the addition of dialkylzincs to both aromatic and aliphatic imines. (C) 2008 Elsevier Ltd. All rights reserved.
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