Journal
TETRAHEDRON-ASYMMETRY
Volume 19, Issue 13, Pages 1515-1518Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.06.022
Keywords
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Funding
- National Natural Science Foundation of China [20672061]
- Nankai University State Key Laboratory of Elemento-organic Chemistry
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A mild and efficient procedure for Michael additions of cyclohexanone to chalcones has been developed. In the presence of amino acid ionic liquid [EMlm][Pro] (200 mol %), cyclohexanone reacted with various chalcones to afford Michael adducts in high yields (85-98%) and moderate to good enantioselectivities (16-94% ee), accompanied by an unexpected solvent-dependent inversion of the enantioselectivity. (C) 2008 Elsevier Ltd. All rights reserved.
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