Journal
TETRAHEDRON-ASYMMETRY
Volume 19, Issue 19, Pages 2276-2284Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.09.020
Keywords
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Funding
- CSIR, India [01/1878/03/EMR-11]
- JRF(NET) fellowship
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Protonated chiral (S)-prolinamide derivatives have been developed as water compatible highly efficient organocatalysts for a direct enantioselective aldol reaction. A simple protonated (S)-prolinamide organocatalyst prepared from L-proline and 3-nitroaniline catalyzes the aldol reaction of unmodified ketones and a variety of aromatic aldehydes yielding aldol product in high yield with enantioselectivities of up to 98% and diastereoselectivity of up to >99:1. (C) 2008 Elsevier Ltd. All rights reserved.
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