A new approach for the asymmetric synthesis of (2S,3S)-3-hydroxypipecolic acid

An efficient stereoselective synthesis of (2S,3S)-3-hydroxypipecolic acid was achieved from (S)-glutamic acid via the furylation of an N-protected 6-hydroxy-2-piperidinone using furan as a nucleophile and the oxidation of the furyl group to a carboxylic group as the key steps. (C) 2008 Elsevier Ltd. All rights reserved.