Journal
TETRAHEDRON LETTERS
Volume 59, Issue 42, Pages 3725-3737Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.08.034
Keywords
Squaramide; alpha-Chiral amine; Asymmetric organocatalysis; Bifunctional organocatalyst
Categories
Funding
- METU-BAP [113Z156]
- TUBITAK [113Z156, 2211/A]
- METU-Central Laboratory
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Enantiomerically pure alpha-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and large-scale applications becomes a major issue. In this respect, chiral bifunctional H-bonding squaramides have been successfully applied for both amine synthesis and functionalization of amines in the last decade. This survey summarizes asymmetric synthesis of chiral amines by various carbon-carbon and carbon-nitrogen bond formation with squaramide catalysis as a particular focus of interest. (C) 2018 Published by Elsevier Ltd.
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