4.4 Article

Pd-catalyzed assembly of phenanthridines from aryl ketone O-acetyloximes and arynes through C-H bond activation

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 5, Pages 1036-1039

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.12.075

Keywords

Arynes; Palladium; C-H bond activation; Phenanthridines; Aryl ketone O-acetyloximes

Funding

  1. National Natural Science Foundation of China [21102043]
  2. China Postdoctoral Science Foundation [20110490070, 2012T50401]
  3. Fundamental Research Funds for the Central Universities

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Pd-catalyzed annulation of aryne and aryl ketone O-acetyloxime via C-H bond activation was realized. Through the C-H bond activation/insertion/cyclization/elimination reaction sequence, phenanthridines are successfully constructed, providing an attractive strategy to approach substituted heterocycle without preactivation of starting materials. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

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