4.4 Article

Ligand-free copper nanoparticle promoted N-arylation of azoles with aryl and heteroaryl iodides

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 4, Pages 941-944

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.12.065

Keywords

Copper nanoparticles; N-Arylindoles; N-Arylpyrroles; Aryl iodides; Ullmann-Goldberg coupling

Funding

  1. DST-PURSE Grant

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A relatively mild, efficient, and inexpensive method for the nucleophilic aromatic substitution of the N-H heterocycles with various aryl and heteroaryl iodides using copper nanoparticles (Cu-NP) is reported. The coupling reaction has been successfully achieved with moderate to good yields. (C) 2013 Elsevier Ltd. All rights reserved.

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