Journal
TETRAHEDRON LETTERS
Volume 55, Issue 14, Pages 2312-2316Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.02.114
Keywords
Copper nanoparticles; Phenylacetylene; Cycloaddition; Click chemistry; Multicomponent reaction
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Funding
- Natural Science Foundation of China [20702042, 21262028]
- Program for Changjiang Scholars and Innovative Research Teams in Universities of the Ministry of Education of China [IRT1177]
- Natural Science Foundation of Gansu Province [1208RJZA140]
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Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times without significant deactivation. (C) 2014 Elsevier Ltd. All rights reserved.
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