Journal
TETRAHEDRON LETTERS
Volume 55, Issue 14, Pages 2249-2252Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.02.075
Keywords
Alloxan; 3-Formylchromone; Isocyanide; Furochromone
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Funding
- Kharazmi University Research Council
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A three-component domino reaction between a 3-formylchromone, an isocyanide, and 1,3-dimethylalloxan which affords novel 5-(furo[3,4-b]chromenyl)-5-hydroxybarbiturate derivatives is reported. The reaction sequence consists of an initial [4+1] cycloaddition followed by an activated electrophilic heteroaromatic substitution on the furan ring to afford the products. This novel cascade reaction sequence represents an atom-economic route to biologically interesting molecules. (C) 2014 Elsevier Ltd. All rights reserved.
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