4.4 Article

Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 13, Pages 2134-2137

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.02.053

Keywords

N-Sulfinyl beta-amino isoxazolyl ketone; tert-Butanesulfinyl ketimine; 1-(3,5-Dimethylisoxazol-4-yl)ethanone; beta-Aryl-beta-methyl aminoalcohol

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A series of beta-disubstituted N-sulfinyl beta-amino isoxazolyi ketones has been prepared by addition of tert-butanesulfinyl ketimines with the n-BuLi-generated enolates of isoxazolyl methyl ketones. (C) 2014 Elsevier Ltd. All rights reserved.

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