Journal
TETRAHEDRON LETTERS
Volume 55, Issue 45, Pages 6286-6291Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.09.100
Keywords
Bacillus sp.; Isocoumarin derivatives; Bacillcoumacins; Inhibition of NO production
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Funding
- 973-Project [2015CB 755900]
- National Hi-Tech 863-Projects [2011AA090701, 2013AA092902]
- COMRA [DY125-15-T-01]
- Sino-German Project [GZ816]
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Chemical examination of the fermentation broth of the marine-derived bacterium Bacillus sp. resulted in the isolation of seven new amicoumacin-type isocoumarin derivatives, namely bacillcoumacins A-G (1-7), together with four known analogues. Their structures were elucidated on the basis of extensive spectroscopic analysis, while the absolute configurations of the new compounds were determined by CD, Mosher's method, and chemical conversion. Compounds 7 and 9 showed inhibitory effects against the NO production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells. (C) 2014 Elsevier Ltd. All rights reserved.
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