Journal
TETRAHEDRON LETTERS
Volume 55, Issue 32, Pages 4496-4500Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.06.057
Keywords
One-pot synthesis; Chalcone epoxides; Epoxidation; Claisen Schmidt condensation
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Funding
- Susquehanna University Summer Partners Program
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Waste minimization is a very important aspect of an environmentally benign protocol. A one-pot consec-process has been developed for chalcone epoxide synthesis that allows compounds to be prepared having to isolate and purify the intermediates. The strategy utilizes consecutive Claisen Schmidt and epoxidation reactions to prepare chalcone epoxides from substituted benzaldehydes acetophenones in good yields. (C) 2014 Elsevier Ltd. All rights reserved.
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