Journal
TETRAHEDRON LETTERS
Volume 55, Issue 30, Pages 4126-4128Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.05.099
Keywords
Maedamide; Marine cyanobacteria; Depsipeptide; Chymotrypsin inhibitor; Lyngbya
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24310160, 25750386]
- MEXT from the Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [25750386] Funding Source: KAKEN
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Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells. (C) 2014 Elsevier Ltd. All rights reserved.
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