4.4 Article

Synthesis of highly substituted indene derivatives by Bronsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 29, Pages 3881-3884

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.05.027

Keywords

Bronsted acid; Homoallylic alcohols; Homogeneous catalysis; Friedel-Crafts reaction; Indene derivatives

Funding

  1. Ministry of Education of Singapore [MOE2013-T1-002-035]
  2. Young National Natural Science Foundation of China Grant [21302096]
  3. Young Natural Science Foundation of Jiangsu Province Grant [BK20130962]
  4. Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions
  5. Yousef Jameel Scholarship

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An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Bronsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described. (C) 2014 Elsevier Ltd. All rights reserved.

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