Journal
TETRAHEDRON LETTERS
Volume 55, Issue 8, Pages 1421-1423Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.035
Keywords
Cespitularia; Diterpenoid; NMR; Cytotoxicity; Anti-inflammatory
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Funding
- Japanese Government (Ministry of Education, Culture, Sports, Science, and Technology)
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An Okinawan soft coral Cespitularia sp. has proven to be a good source of cytotoxic metabolites having a carbon skeleton of the seco-type variety of xenicin. This soft coral yielded alcyonolide, the major constituent, and other related compounds, all of which have proven to be cytotoxic. Reinvestigation of the cytotoxic ethyl acetate extracts of the coral yielded two new alcyonolide congeners, trisnorditerpenoid 1 and diterpenoid 2, possessing the same carbon skeleton. Their structures were elucidated by a detailed analysis of spectroscopic data (1D, 2D NMR, and MS). Metabolites 1 and 2 showed cytotoxicity against HCT116 cells (IC50 6.04 and 47.0 mu M, respectively) and a dose dependent, anti-inflammatory effect in LPS/IFN-gamma-stimulated inflammatory RAW 264.7 macrophage cells. (C) 2014 Elsevier Ltd. All rights reserved.
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