I2-DMSO catalyzed synthesis of 1,2,2-triarylethanones via dual C-H activation of aryl methyl ketones

An l(2)-DMSO promoted domino protocol was developed for the synthesis of 1,2,2-triarylethanones from readily available aromatic methyl ketones and methoxybenzenes. The 1,2,2-triarylethanones are important precursors for the synthesis of Tamoxifen and Droloxifene. The use of mild reaction conditions, high yield, and single step synthesis are the advantages of the present protocol. (c) 2014 Elsevier Ltd. All rights reserved.