Journal
TETRAHEDRON LETTERS
Volume 55, Issue 10, Pages 1815-1817Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.122
Keywords
Alstonia scholaris; Indole alkaloids; Anti-adenovirus; Anti-HSV
Categories
Funding
- National Natural Science Foundation of China [31270396]
- National Basic Research Program of China (973 Program) [2014CB138703]
- 111 Project of China
Ask authors/readers for more resources
A novel alkaloid, 17-nor-excelsinidine (1), possessing an unusual 1-azoniatricyclo [4.3.3.0] undecane moiety was isolated from the twigs and leaves of Alstonia scholaris alongside its biogenetically related strictamine (2). The structure and absolute stereochemistry of compound 1 were rigorously determined by a combination of NMR spectroscopy and X-ray crystallography. The 17-nor-excelsinidine (1) and strictamine (2) showed significant inhibitory activity against herpes simplex virus (HSV) and adenovirus (ADV). (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
