Journal
TETRAHEDRON LETTERS
Volume 55, Issue 8, Pages 1448-1451Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.044
Keywords
Nitrilase; Dynamic kinetic resolution; Biphasic system; D-Phenylglycine
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Funding
- National Basic Research Program of China [2012CB721003]
- Fundamental Research Funds for the Central Universities
- National Major Science and Technology Projects of China [2012ZX09304009]
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A strategy of nitrilase mediated dynamic kinetic resolution toward the synthesis of D-phenylglycine was developed, using aqueous-l-octanol biphasic system. Due to the efficient suppression of the decomposition of phenylglycinonitrile, a maximum yield of 81% is obtained. This result indicates that the nitrilase mediated dynamic kinetic resolution is a promising method toward the synthesis of D-phenylglycine and its derivatives. (C) 2014 Elsevier Ltd. All rights reserved.
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