Journal
TETRAHEDRON LETTERS
Volume 55, Issue 34, Pages 4716-4719Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.07.019
Keywords
Sponge; Ircinia sp.; Sesquiterpenoids; PPAR delta; Obesity
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Funding
- Ministry of Land, Transport, and Maritime Affairs of Korea
- Ewha Global Top5 Grant of Ewha Womans University
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One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPAR delta agonistic activities, with EC50 values of 18 and 30 mu g/mL, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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