Journal
TETRAHEDRON LETTERS
Volume 55, Issue 24, Pages 3507-3510Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.04.089
Keywords
5-Substituted 1H-tetrazole; Trispentafluorophenyl borane [B(C6F5)(3)]; Nontoxic; NaN3; [3+2] Cycloaddition
Categories
Funding
- Department of Pharmaceuticals (Ministry of Chemicals and Fertilizers)
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A simple and efficient protocol is developed for the synthesis of 5-substituted 1H-tetrazole derivatives from various nitriles and sodium azide (NaN3) via [3+2] cycloaddition reaction using B(C6F5)(3) as a catalyst. The present synthetic method displayed significant advantages such as low catalyst loading, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups. (C) 2014 Elsevier Ltd. All rights reserved.
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