Journal
TETRAHEDRON LETTERS
Volume 55, Issue 43, Pages 5908-5910Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.09.001
Keywords
N-Sulfonyl imines; alpha,alpha-Difluoroenolates; Pentafluoro-beta-di-ketone hydrate; C-C bond cleavage; Mannich reaction
Categories
Funding
- National Natural Science Foundation of China [21102071]
- Fundamental Research Funds for the Central Universities [1107020522, 1082020502]
- Jiangsu 333 Program
- Changzhou Jin-Feng-Huang Program
Ask authors/readers for more resources
We report here that the reactions of in situ generated unprotected alpha,alpha-difluoroenolates with various N-sulfonyl imines take place under operationally convenient conditions affording a novel type of fluorinated sulfonamides of high pharmaceutical potential. The reactions feature structural generality, excellent yields and can be easily scaled up for practical preparation of the target fluorine-containing sulfonamides. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available