Journal
TETRAHEDRON LETTERS
Volume 55, Issue 43, Pages 5908-5910Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.09.001
Keywords
N-Sulfonyl imines; alpha,alpha-Difluoroenolates; Pentafluoro-beta-di-ketone hydrate; C-C bond cleavage; Mannich reaction
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Funding
- National Natural Science Foundation of China [21102071]
- Fundamental Research Funds for the Central Universities [1107020522, 1082020502]
- Jiangsu 333 Program
- Changzhou Jin-Feng-Huang Program
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We report here that the reactions of in situ generated unprotected alpha,alpha-difluoroenolates with various N-sulfonyl imines take place under operationally convenient conditions affording a novel type of fluorinated sulfonamides of high pharmaceutical potential. The reactions feature structural generality, excellent yields and can be easily scaled up for practical preparation of the target fluorine-containing sulfonamides. (C) 2014 Elsevier Ltd. All rights reserved.
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