Journal
TETRAHEDRON LETTERS
Volume 55, Issue 40, Pages 5508-5510Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.08.056
Keywords
Pinnatoxin; Portimine; Vulcanodinium; Cyclic imine; Algal toxin
Categories
Funding
- New Zealand Ministry for Business, Innovation and Employment [CAWX1317]
Ask authors/readers for more resources
Pinnatoxin H was isolated from a culture of the dinoflagellate Vulcanodinium rugosum isolated from the South China Sea. The structure of pinnatoxin H was elucidated by LC-MS/MS and NMR spectroscopy. It was found to have the same macrocyclic structure and substituents as pinnatoxins D, E and F, but the side chain on the cyclohexenyl ring was an ethenyl group, as found in pinnatoxin G and portimine. The observation that this strain of V. rugosum produced only pinnatoxin H and portimine is consistent with previous findings that the profile of pinnatoxins can vary significantly among strains. The acute toxicity of pinnatoxin H to mice was 67 mu g/kg (intraperitoneal) and 163 mu g/kg (gavage). (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available