Journal
TETRAHEDRON LETTERS
Volume 55, Issue 9, Pages 1640-1643Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.090
Keywords
Monascus azaphilone pigment biosynthesis; Monascus purpureus; Knoevenagel aldol condensation; Targeted inactivation of mpp7
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education [2011-0021169, 2013R1A1A2059458]
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Targeted inactivation of the mpp7 gene in the Monascus azaphilone pigment (MAzP) biosynthetic gene cluster resulted in the accumulation of monasfluol A (7) and B (8), of which the latter was a novel compound, and the abolition of the main MAzPs. It is thus proposed that 7 and 8 are the products of nonenzymatic Knoevenagel condensation followed by a reduction and that Mpp7 assists in regioselective Knoevenagel aldol condensation during MAzP biosynthesis. (C) 2014 Elsevier Ltd. All rights reserved.
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