Journal
TETRAHEDRON LETTERS
Volume 55, Issue 10, Pages 1711-1714Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.096
Keywords
Aplysia oculifera; Opisthobranch; Halogenated sesquiterpenes; Cytotoxicity
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Funding
- National Research Center, Cairo, Egypt
- Robert Welch Foundation, USA [D-1478]
- Grants-in-Aid for Scientific Research [25350965] Funding Source: KAKEN
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Two new sesquiterpenes, oculiferane (1) and epi-obtusane (2) have been isolated and identified from an acetone extract of the digestive gland of the sea hare, Aplysia oculifera. The structures were elucidated by spectroscopic analysis including HREIMS, H-1, C-13, DEPT, H-1-H-1 COSY, HMQC, and HMBC NMR; the relative configuration was confirmed by X-ray analysis. Compounds 1 and 2 exhibited cytotoxic activity in vitro against several human cancer cell lines with IC50 values in the low mu g/ml range. (C) 2014 Elsevier Ltd. All rights reserved.
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