4.4 Article

Gold-catalyzed cascade C-C and C-N bond formation: synthesis of polysubstituted indolequinones and pyrroles

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 44, Pages 5898-5900

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.100

Keywords

Gold catalysis; Cascade reaction; Pyrrole; Indolequinone; Enamine

Funding

  1. National Natural Science Foundationof China [21172106, 21074054]
  2. National Basic Research Program of China [2010CB923303]
  3. Research Fund for the Doctoral Program of Higher Education of China [20120091110010]

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The combination of Ph3PAuCl and AgoTf was proven to be an efficient catalyst for the cascade C-C and C-N bond formation reactions from enamines and bromoquinones or nitroolefins. This protocol affords a straightforward method for the synthesis of polysubstituted indolequinones and pyrroles in good yields. (C) 2013 Elsevier Ltd. All rights reserved.

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