Journal
TETRAHEDRON LETTERS
Volume 54, Issue 36, Pages 4834-4836Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.06.081
Keywords
Illicium henryi; Illiciaceae; Sesquiterpene lactone; Nor-sesquiterpene lactone; Anti-HBV activity
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81172961]
- External Cooperation Program of Chinese Academy of Sciences [p2009-KF10]
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Henrylactone F (1), an unusual nor-sesquiterpene lactone, together with a pair of stereoisomers, henrylactone G (2) and anislactone B (3), was discovered from the fruits of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses as well as X-ray diffraction. The anti-hepatitis B virus (HBV) activity of the isolates against the HBV transfected Hep G2.2.15 cell line was evaluated. Anislactone B (3) possessed a high therapeutic index (TI = 43.4) on HBeAg secretion of the Hep G2.2.15 cell line with an IC50 value of 0.079 +/- 0.035 mM. (C) 2013 Elsevier Ltd. All rights reserved.
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