Journal
TETRAHEDRON LETTERS
Volume 54, Issue 30, Pages 3967-3970Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.05.081
Keywords
Tribulus terrestris; Furostanol glycoside; Terrestrinone A1; Nitric oxide inhibitor
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Funding
- High Value-added Food Technology Development Program, Ministry for Food, Agriculture, Forestry and Fisheries [111130-03-1-HD110]
- Region-Specific Technology Convergence Studies Support Business, the Ministry of Knowledge Economy (MKE), Republic of Korea [R0002039]
- Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea [R0002039] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Two new furostanol glycosides, named terrestrinones A1/A2 (1a/1b), were isolated from the fruits of Tribulus terrestris L. together with four known compounds, and their structures were determined by spectroscopic methods, including 20 NMR experiments. All of the isolates (1-5) were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. Of these, compounds 2 and 3 inhibited nitric oxide production with IC50 values of 7.1 and 46.6 mu M. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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