☆ 4.4 Article

A simple, three-component synthesis of 2-aminothiazoles using trimethylsilyl isothiocyanate

TETRAHEDRON LETTERS (2013)

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Journal

TETRAHEDRON LETTERS
Volume 54, Issue 36, Pages 4844-4847

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.06.102

Keywords

2-Aminothioazoles; Multicomponent reactions; Combinatorial chemistry; Privileged structures; Parallel solution-phase synthesis

Categories

Chemistry, Organic

Funding

  1. Griffith University

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The first multicomponent, solution-phase protocol to prepare privileged 2-aminothiazoles from alpha-bromocarbonyl compounds and amines (aromatic and aliphatic) using commercially available trimethylsilyl isothiocyanate is described. (C) 2013 Elsevier Ltd. All rights reserved.

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