Journal
TETRAHEDRON LETTERS
Volume 54, Issue 37, Pages 5052-5055Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.028
Keywords
Topo II inhibitor; Caesalpinia ferrea Mart; Chalcone dimer; trans-Substituted dihydrobenzofuran; Absolute configuration
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New chalcone dimers, pauferrol B (2), and pauferrol C (3), were isolated from the stems of Caesalpinia ferrea Mart, and their structures were determined on the basis of 2D NMR spectroscopy. These new chalcone dimers showed potent inhibitory activities against human topoisomerase II and cell proliferation via the induction of apoptosis in human leukemia HL 60 cells. Absolute configurations of 2 and 3 were estimated by the comparison of CD spectra with a dihydrobenzofuran derivative 4, which was enantioselectively synthesized from 2-hydroxyphenyl acetic acid. (C) 2013 Elsevier Ltd. All rights reserved.
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