Journal
TETRAHEDRON LETTERS
Volume 54, Issue 14, Pages 1884-1887Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.01.113
Keywords
C2-Functionalized pyrimidines; Oxidative aromatization; 3,4-Dihydropyrimidin-2(1H)-ones; S-N coupling; C-N coupling
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Funding
- National Nature Science Foundation of China [20902073, 21062017]
- Northwest Normal University [nwnu-kjcxgc-03-64]
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A domino S-N and C-N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S-N and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C-N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction. (C) 2013 Elsevier Ltd. All rights reserved.
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