Journal
TETRAHEDRON LETTERS
Volume 54, Issue 49, Pages 6700-6702Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.09.085
Keywords
Aurachin D; Total synthesis; Natural products; Myxobacteria; Quinoline alkaloids
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Aurachins, a family of isoprenoid quinoline alkaloids isolated from the myxobacterium Stigmatella aurantiaca, possess multiple interesting bioactivities and were subject of intensive studies of biosynthesis. In this Letter, we describe the efficient few step total synthesis of the parent compound aurachin D and two isoprenoid analogues via Conrad-Limpach cyclization. The main antimicrobial and cytotoxic profiles of these derivatives were explored. (C) 2013 Elsevier Ltd. All rights reserved.
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