4.4 Article

Palladium-catalyzed asymmetric hydrogenation of dibenzo[b,f][1,4]thiazepines activated by Bronsted acid

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 45, Pages 5956-5959

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.068

Keywords

Dihydrodibenzothiazepines; Palladium; Asymmetric hydrogenation

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An efficient and facile route to chiral dihydrodibenzothiazepines has been successfully developed via palladium-catalyzed asymmetric hydrogenation of the dibenzothiazepines with Bronsted acid as activator with up to 94% ee. (C) 2013 Elsevier Ltd. All rights reserved.

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