4.4 Article

Toward waste-free peptide synthesis using ionic reagents and ionic liquids as solvents

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 21, Pages 2703-2705

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.03.072

Keywords

Ionic liquids; Imidazolium triflate; Peptide coupling; Coupling reagent; Carbonyldiimidazole

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CBEIT 1, an ionic coupling reagent, gives access to amino acid carbamates, and allows waste-free peptide coupling. The only by-products are carbon dioxide and ethylimidazolium triflate that is an ionic liquid playing the role of the solvent. (c) 2013 Elsevier Ltd. All rights reserved.

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