Journal
TETRAHEDRON LETTERS
Volume 54, Issue 23, Pages 3003-3006Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.03.119
Keywords
Chemodosimeter; Cysteine; Fluorescence; Probe
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Funding
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2011-0028456]
- National Research Foundation of Korea [2011-0028456] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A bromoacetyl functionalized fluorescein chemodosimeter (1) was utilized as a fluorescent probe for cysteine. The probe showed a selective and sensitive response to cysteine over homocysteine and glutathione in aqueous buffer through a rapid cyclization reaction. When cysteine was added, a fast fluorescence turn-on change of 1 was observed, thus allowing cysteine to be discriminated from other biothiols and micromolar concentrations of cysteine to be detected by the naked eye. (C) 2013 Elsevier Ltd. All rights reserved.
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