4.4 Article

One-step enantioselective synthesis of (4S)-isosclerone through biotranformation of juglone by an endophytic fungus

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 10, Pages 1189-1191

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.12.038

Keywords

Biotransformation; Endophytic fungus; Naphthalenone pentaketide; Secondary metabolites; Circular dichroism

Funding

  1. Fondation pour la Recherche sur la Biodiversite [AAP-IN-2009-026]
  2. Action Transversale du Museum 'Biodiversite des microorganismes dans les ecosystemes actuels et passes' from the Museum national d'Histoire naturelle

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We describe here a direct access to (4S)-isosclerone (+)-1, an important structural component of several natural products featuring a spirobisnaphthalene ring system. Starting with the commercially available 5-hydroxy-1,4-naphthalenedione (juglone), biotransformation by the isosclerone-producing endophytic fungus Paraconiothyrium variabile is described. The absolute configuration of (+)-1 was determined unambiguously using circular dichroism and by measurement of the optical rotation. Moreover, the bio-transformations of other naphthalene derivatives were undertaken and led to the corresponding (4S)-hydroxy-l-tetralone. At last, this work brings some insights on the biosynthesis of natural tetralones. (C) 2012 Elsevier Ltd. All rights reserved.

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