Journal
TETRAHEDRON LETTERS
Volume 54, Issue 9, Pages 1076-1079Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.12.034
Keywords
Biginelli reaction; Catalyst-free; Solvent-free; Green chemistry; Tetrahydropyrimidine
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Funding
- Deanship of Scientific Research at King Saud University [RGP-VPP-026]
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A series of novel ethyl 2-oxo/thio-4-aryl-6-(arylsulfonylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylates has been synthesized regioselectively by the Biginelli reaction of ethyl 3-oxo-4-(arylsulfonyl)butanoate, aromatic aldehyde and urea/thiourea under microwave irradiation and solvent- and catalyst-free conditions. (C) 2012 Elsevier Ltd. All rights reserved.
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