Journal
TETRAHEDRON LETTERS
Volume 54, Issue 33, Pages 4373-4376Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.05.139
Keywords
Green chemistry; Benzo[b]thiophenes; Electrophilic cyclization; Iodocyclization; Bromocyclization; Chlorocyclization
Categories
Funding
- Bard Summer Research Institute
- National Science Foundation Major Research Instrumentation Award [1039659]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1039659] Funding Source: National Science Foundation
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We have developed a greener process for the synthesis of 2,3-disubstituted benzo[b]thiophenes using electrophilic cyclization as a key step. Our method not only employs an environmentally friendly solvent ethanol, but also utilizes safe and inexpensive inorganic reagents to furnish the desired products in high yields under mild reaction conditions. In addition to iodo- and bromocyclization, chlorocylization was also successfully accomplished. (c) 2013 Elsevier Ltd. All rights reserved.
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