Journal
TETRAHEDRON LETTERS
Volume 54, Issue 41, Pages 5591-5596Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.157
Keywords
2,4,6-Trichloro-1,3,5-triazine; Cyanuric chloride; Fischer indole synthesis; Mild catalyst; Carbazole
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Mild and efficient protocol for the Fischer indole synthesis using TCT has been described. TCT serves as a mild and inexpensive catalyst. Under these conditions several functional groups such as ester, cyano, sulfone, amides, and ethers are tolerated. By this method, many functionalized analytically pure indoles were prepared easily without the need of purification. (C) 2013 Elsevier Ltd. All rights reserved.
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