Journal
TETRAHEDRON LETTERS
Volume 54, Issue 38, Pages 5197-5200Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.068
Keywords
Huperzia saururus; N-Demethyl-sauroxine; Acetylcholinesterase inhibition; Sauroxine NMR two dimensional data
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Funding
- SeCyT-Universidad Nacional de Cordoba [05/C375]
- ANPCyT [BID-PICT 1576]
- CONICET [D32/10]
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The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 +/- 1.1 mu M). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data. (C) 2013 Elsevier Ltd. All rights reserved.
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