Journal
TETRAHEDRON LETTERS
Volume 54, Issue 37, Pages 5099-5102Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.045
Keywords
Carboxamides; Tosylamides; Isocyanates; N-Acylureas; Hofmann rearrangement; Organocatalysts
Categories
Funding
- CSIR, New Delhi
Ask authors/readers for more resources
A novel, efficient, and operationally simple one-pot synthesis of both, symmetrical and unsymmetrical N-acylureas from carboxamides and in situ generated isocyanates (from N,N-dibromo-p-toluenesulfonamide) in the presence of a mild base at rt is reported. The protocol avoids the tedious isolation and purification steps of hazardous isocyanates. The first application of these acylureas to the catalysis through hydrogen bonding is also demonstrated. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available