4.4 Article

First total synthesis of neurotrophic diacetylene tetrol (-)-petrosiol D

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 47, Pages 6370-6372

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.09.058

Keywords

Cadiot-Chodkiewicz coupling; Bromo acetylene; Neurite; Outgrowth; Polyol; Acetonide

Funding

  1. CSIR, New Delhi [CSC-0108]

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The first total synthesis of the natural product (-)-petrosiol D has been achieved in a linear fashion. Sharpless asymmetric epoxidation, base induced elimination reaction for the formation of chiral propargyl alcohol and Cadiot-Chodkiewicz coupling reaction are the key steps utilized for the synthesis. (C) 2013 Elsevier Ltd. All rights reserved.

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