RCM strategy-based entry into new crown ether/polyether macrocyclic systems derived from hydroxy benzaldehydes

Entry into the 16-24 membered new crown ether/polyether macrocyclic molecules and the post ring-closure functional derivatization/periphery modification of polyether macrocyclic systems are reported. The synthesis of the epoxide, alpha-hydroxy ketone and olefinic functionality installed crown ether/polyether macrocyclic molecules was accomplished using the ring closing metathesis (RCM), epoxidation, oxidation and catalytic hydrogenation-based synthetic transformations starting from various hydroxy benzaldehydes. (C) 2013 Elsevier Ltd. All rights reserved.