4.4 Article

Biocatalytic asymmetric aldol reaction in buffer solution

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 8, Pages 945-948

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.12.022

Keywords

Biocatalysis; Asymmetric cross-aldol reaction; Bovine pancreatic lipase; Buffer solution

Funding

  1. National Natural Science Foundation of China [21001077, 20121001]
  2. Program for Changjiang Scholars and Natural Science Foundation of Jiangxi [20114BAB213003, 20122BAB203006]

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A green and convenient protocol has been developed for asymmetric cross-aldol reaction. In this Letter, bovine pancreatic lipase (BPL) was first reported to catalyze the aldol reaction and acidic buffer was first used for promiscuous enzymatic aldol reaction. (C) 2012 Elsevier Ltd. All rights reserved.

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