Journal
TETRAHEDRON LETTERS
Volume 54, Issue 5, Pages 370-372Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.10.133
Keywords
Aminocarboxylic acid; Lactam; Ring-closure; Lipase
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Funding
- Ubbo Emmius Programme of the University of Groningen
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The formation of e-caprolactam from 6-aminocaproic acid catalyzed by CALB (N435) is reported. Different lactam ring sizes can be prepared starting from 4-aminobutanoic acid, 5-aminovaleric acid, and 8-aminooctanoic acid. Experiments with mixtures of aminocarboxylic acids have shown that CALB prefers homocyclization of the individual aminocarboxylic acids. (C) 2012 Elsevier Ltd. All rights reserved.
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