Journal
TETRAHEDRON LETTERS
Volume 54, Issue 8, Pages 883-886Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.123
Keywords
Ochratoxin alpha synthesis; Analytical standard; Ochratoxin A (OTA); Directed ortho-metalation; Metalation of unprotected benzoic acids
Categories
Funding
- Brazilian National Council for Scientific and Technological Development (CNPq)
Ask authors/readers for more resources
Two new routes for the synthesis of enantiomerically pure ochratoxin alpha ((3R)-OT alpha) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid (L)-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LIMP) and (R)-propylene oxide. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available