Journal
TETRAHEDRON LETTERS
Volume 54, Issue 33, Pages 4475-4478Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.06.043
Keywords
Amides; Boronic acids; Heterogeneous catalysis; Solid-phase
Categories
Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- University of Alberta
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Amides are a ubiquitous class of organic compounds endowed with great utility. There is a need for simple and effective catalytic methods for their direct formation from carboxylic acids and amines as a way to avoid the use of coupling reagents. We have designed a recyclable resin-supported derivative of 5-methoxy-2-iodophenylboronic acid as a heterogeneous catalyst active in ambient conditions for promoting direct amidations of aliphatic carboxylic acids and amines. The optimal, practical procedure involves a simple double-filtration to isolate the amide product while separating the catalyst from residual molecular sieves. (C) 2013 Elsevier Ltd. All rights reserved.
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